Asymmetric Copper-Catalyzed Azide–Alkyne Cycloadditions

Enantioselective copper-catalyzed 1,3-dipolar cycloadditions.

Copper(II)-catalyzed exo and enantioselective cycloadditions of azomethine imines.

A strategy for exo and enantioselective 1,3-dipolar cycloaddition of azomethine imines to 2-acryloyl-3-pyrazolidinone is described. The corresponding cycloadducts are isolated with high diastereoselectivities (up to >96:4 exo/endo) and enantioselectivities (up to 98% ee).

Iridium–catalyzed 1,3–dipolar cycloadditions

1,3–Dipolar cycloaddition reactions (DCR) are atom–economic processes that permit the construction of heterocycles. Their enantioselective versions allow for the creation of up to four adjacent chiral centers in a concerted fashion. In particular, well–defined half–sandwich iridium (III) catalysts have been applied to the DCR between enals or methacrylonitrile with nitrones. Excellent yield and...

Dynamic kinetic asymmetric transformation in copper catalyzed allylic alkylation.

The first dynamic kinetic asymmetric transformation in copper catalyzed allylic alkylation is reported, with enantioselectivities up to 92%.

Regiodivergent 1,4 versus 1,6 asymmetric copper-catalyzed conjugate addition.